Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast

摘要

The sulfur assimilation and phospholipid biosynthesis pathways interact metabolically and transcriptionally. Genetic analysis, genome-wide sequencing, and expression microarrays show that regulators of these pathways, Met4p and Opi1p, control cellular methylation capacity that can limit the growth rate.